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1.
Int. j. odontostomatol. (Print) ; 17(3): 274-280, sept. 2023. ilus, tab
Artigo em Espanhol | LILACS | ID: biblio-1514384

RESUMO

El desplazamiento de un tercer molar a un espacio anatómico adyacente, ya sea en su totalidad o un fragmento de este, se encuentra descrito como una complicación rara pero posible de las exodoncias de terceros molares. En este reporte se aborda específicamente el desplazamiento accidental de un tercer molar inferior hacia el espacio submandibular izquierdo, el cual fue resuelto quirúrgicamente mediante un abordaje intraoral bajo anestesia general por el equipo de cirugía maxilofacial del Hospital de Urgencia Asistencia Pública, Santiago, Chile. Se realizó una revisión de literatura en la plataforma PubMed con las palabras claves "third molar - submandibular - displacement" obteniendo un total de 17 artículos en los cuales se reportan 15 casos. El propósito del presente escrito fue presentar recomendaciones sobre el manejo actual de esta complicación en base a la literatura disponible.


The displacement of a third molar into an adjacent anatomical space, either in its entirety or a fragment of it, has been described as a rare but posible complication of third molar extractions. This report will specifically address the accidental displacement of a lower third molar into the left submandibular space, which was surgically removed through an intraoral approach under general anesthesia, by the maxillofacial surgeon team of "Hospital de Urgencia Asistencia Pública", Santiago, Chile. An literature review was carried out on PubMed platform with the keywords ""third molar - submandibular - displacement"", obtaining a total of 17 articles where are reported 15 cases. The purpose of this paper is to present recommendations on the current management of this complication based on the available literature.


Assuntos
Humanos , Masculino , Adulto , Migração de Dente , Complicações Intraoperatórias , Dente Serotino/cirurgia , Glândula Submandibular/cirurgia
2.
Clin Implant Dent Relat Res ; 25(6): 1080-1090, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-37496294

RESUMO

PURPOSE: The objectives of this study are to: (1) investigate the extent of antagonistic and distal neighboring tooth migration in the maxillary posterior single tooth-missing site during the healing period of bone augmentation and implant surgery; (2) identify factors associated with tooth migration. MATERIALS AND METHODS: One hundred and forty-three cases that lost the maxillary first molar were included, and their CBCT data during the edentulous period were obtained. Dentition models were reconstructed from CBCT, and superimpositions were performed, followed by measuring migration distances and calculating migration rates of antagonistic and distal neighboring teeth. Factors were analyzed using multivariate generalized estimating equations (GEE). RESULTS: The mean migration distances were 208 ± 137 µm and 403 ± 605 µm for antagonistic teeth and distal teeth, and the mean migration rates were 26.8 ± 21.2 µm/month and 48.5 ± 76.7 µm/month, respectively. One hundred and nineteen out of 143 distal neighboring teeth migrated toward the edentulous site, and all antagonistic teeth migrated occlusally. Occlusal contact loss and chronic apical periodontitis both significantly accelerated antagonistic tooth migration (p < 0.05), the latter also accelerated distal tooth migration (p < 0.05). Besides, the displacement of the distal teeth was somewhat accelerated by the impacted adjacent third molar and root protrusion into the sinus. CONCLUSIONS: The neighboring teeth tend to migrate toward the edentulous gap in the maxillary posterior region. Occlusal contact loss and chronic apical periodontitis are two significant risk factors for accelerating antagonistic tooth migration, and for distal teeth, chronic apical periodontitis is the risk factor. The impacted adjacent third molar and root protrusion into the sinus are also potential risk factors for accelerating the migration of the maxillary distal tooth. Thus, to prevent maxillary edentulous gap reduction, the factors mentioned above should be taken into consideration when planning treatment flow.


Assuntos
Boca Edêntula , Periodontite Periapical , Migração de Dente , Humanos , Estudos Retrospectivos , Dente Molar , Seio Maxilar , Migração de Dente/etiologia , Tomografia Computadorizada de Feixe Cônico
3.
J Esthet Restor Dent ; 35(8): 1171-1185, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-37350421

RESUMO

OBJECTIVE: The aim of this case report was to demonstrate the long-term effects of a multidisciplinary approach involving periodontal reconstructive surgery and strategic implant placement before orthodontic (SIMBO) treatment in a patient with severe periodontitis (e.g., stage IV/grade C). CLINICAL CONSIDERATIONS: The patient presented with severe periodontitis and pathologic tooth migration (PTM) without stable occlusion or occlusal support. After performing cause-related therapy, periodontal regenerative surgery, pre-orthodontic posterior implant placement, and orthodontic treatment involving anterior implant placement with papilla reconstruction, the patient achieved full-mouth rehabilitation and improvement of dental and smile esthetics. The clinical and radiographic results obtained were maintained over a 10-year period. CONCLUSION: Within the limits of this as a single case, multidisciplinary treatment involving the SIMBO approach appeared to allow long-term improvement of periodontal condition, stability of the dental arches and occlusion, and esthetics in a patient with severe periodontitis, PTM and posterior bite collapse. Future studies with more subjects are needed to evaluate and validate this approach. CLINICAL SIGNIFICANCE: When addressing periodontal disease, SIMBO approach-based multidisciplinary treatment appears safe and effective as a clinical protocol for establishing esthetic and functional rehabilitation in generalized stage IV/grade C periodontitis.


Assuntos
Periodontite , Migração de Dente , Dente , Humanos , Seguimentos , Periodontite/complicações , Periodontite/terapia , Migração de Dente/terapia
4.
Clin Adv Periodontics ; 13(4): 258-265, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-37126210

RESUMO

INTRODUCTION: Advances in implant dentistry, often influence our clinical treatment planning and steer us as periodontists from our fundamental values of preserving teeth. Pathologic tooth migration (PTM) of maxillary anterior teeth is a common sequela of periodontitis in patients and results in significant esthetic and functional problems. Patients' growing concern about the esthetics of their teeth and their fears of losing teeth are often reasons for them to seek treatment. We commonly assign a hopeless prognosis to these pathologically migrated teeth because of the significant loss of periodontal support and go with the "safer" choice of replacing them with implants. The purpose of this case report is to present the long-term (7-year) periodontal stability of compromised teeth and to emphasize the successful outcomes achieved when orthodontics, non-surgical periodontal, and restorative treatments are combined. METHODS AND RESULTS: A 38-year-old, otherwise healthy male with compromised function and esthetics, PTM, periodontal disease, and missing teeth presented to our clinic. Primary treatment objectives were to 1) eliminate the periodontal inflammation and 2) restore and stabilize the occlusion by employing non-surgical periodontal treatment, adult orthodontics, and prosthodontics. Following interdisciplinary treatment, clinical and radiographic re-evaluation revealed significant clinical attachment gain, reduction in tooth mobility, favorable esthetics, and better overall prognosis. At an 84-month follow-up, the patient was periodontally healthy and retained his natural dentition. CONCLUSIONS: Interdisciplinary collaboration along with patient compliance may increase the longevity of periodontally compromised teeth and improve esthetics for periodontitis patients who suffer from PTM. Such long-term favorable outcomes reaffirm the value of classic periodontal treatment and the success of multidisciplinary treatment to save teeth as a viable alternative to the extraction of teeth and the placement of implant retained restorations.


Assuntos
Doenças Periodontais , Periodontite , Migração de Dente , Dente , Adulto , Humanos , Masculino , Seguimentos , Periodontite/terapia , Migração de Dente/terapia
5.
Eur J Orthod ; 45(4): 418-429, 2023 07 31.
Artigo em Inglês | MEDLINE | ID: mdl-36869811

RESUMO

BACKGROUND: Literature is scarce on malocclusion prevalence and orthodontic treatment need (OTN) in subjects with stage III-IV periodontitis. Study aims were to assess prevalence of primary and secondary malocclusions in subjects with stage III-IV periodontitis and OTN based on pathologic tooth migration (PTM) and occlusal trauma of anterior teeth (AT). SUBJECTS AND METHODS: One hundred and twenty-one subjects with stage III-IV periodontitis were examined. A comprehensive periodontal-orthodontic examination was performed. Exclusion criteria: age <30 years, removable prosthetics, uncontrolled diabetes, pregnancy/lactation, and oncologic disease. RESULTS: Class II malocclusion was found in 49.6% (Class II div 1-20.7%, Class II div 2-9.9%, subdivision Class II-19.0%), Class I-31.4%, Class III-10.7%, no malocclusion-8.3% of subjects. PTM was observed in 74.4% of maxillary and 60.3% of mandibular AT. Spacing and extrusion were the main types of PTM of AT. Odds ratio for PTM of maxillary AT was 9.3 in cases with >30% of sites with clinical attachment loss ≥5 mm (P = 0.001). Spacing of maxillary AT was influenced by periodontitis, Class III malocclusion, and lost teeth. Tongue habit had impact on spacing of mandibular AT. Dental Health Component of Index of Orthodontic Treatment Need yielded that OTN was found in >50% and OTN due PTM, occlusal trauma and impaired function in 66.1% of subjects. CONCLUSIONS: The most prevalent malocclusion was Class II. Spacing and extrusion were prevalent types of PTM of AT. OTN was found in more than half of the subjects. The study highlights the need for preventive measures for PTM in subjects with stage III-IV periodontitis.


Assuntos
Oclusão Dentária Traumática , Má Oclusão Classe II de Angle , Má Oclusão , Periodontite , Migração de Dente , Feminino , Humanos , Adulto , Estudos Transversais , Oclusão Dentária Traumática/complicações , Má Oclusão/epidemiologia , Má Oclusão/complicações , Má Oclusão Classe II de Angle/terapia , Má Oclusão Classe II de Angle/complicações , Periodontite/epidemiologia , Migração de Dente/complicações , Migração de Dente/terapia
6.
Pan Afr Med J ; 41: 39, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35382057

RESUMO

A common consequence of moderate to extreme periodontitis is pathologic migration. This denotes tooth movement when the periodontal disease interjects the equilibrium among the elements that preserve physiological tooth position. The balancing factors can migrate the teeth in any direction. The etiology of pathological migration tends to be multifactorial, thus achieving early diagnosis is imperative, which will ultimately lead to the prompt removal of the etiological factors while avoiding severe bone destruction. In this case maxillary central incisors had diastema due to pathological migration with mobility grade I in maxillary left central incisor. Many cases of moderate to severe pathological migration need a suitable, interdisciplinary approach. Nevertheless, since it is possible to detect mild cases of Pathological tooth migration (PTM) at an early stage, spontaneous correction of migrated teeth can be accomplished by periodontal therapy alone. Regardless of the treatment selected, maintenance of stable results should be considered as an aim of treatment.


Assuntos
Diastema , Doenças Periodontais , Periodontite , Migração de Dente , Diastema/etiologia , Diastema/patologia , Diastema/terapia , Humanos , Incisivo/patologia , Doenças Periodontais/complicações , Periodontite/complicações , Periodontite/cirurgia , Migração de Dente/etiologia , Migração de Dente/patologia , Migração de Dente/terapia
8.
J Am Dent Assoc ; 152(6): 471-482.e2, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-34044978

RESUMO

BACKGROUND AND OVERVIEW: Patients with severe periodontitis often experience pathologic tooth migration (PTM), which impairs esthetics and leads to occlusal disharmony (for example, premature contacts and traumatic occlusion) that can further exacerbate periodontitis. The authors describe a patient who exhibited severe periodontitis with PTM-related bimaxillary protrusion. This report includes 3-year clinical outcomes after periodontal regenerative therapy, implant-anchored orthodontic therapy, and implant prosthodontics intended to achieve both functional and esthetic improvements. CASE DESCRIPTION: A 63-year-old woman sought treatment with the chief complaint of maxillary anterior tooth mobility. Clinical examination revealed excessive tooth mobility, deep periodontal pockets, and infrabony defects in all teeth. All teeth exhibited PTM; the mandibular anterior teeth exhibited marked protrusion caused by the progression of periodontitis. After initial periodontal therapy, periodontal regenerative therapy was performed in all molar regions. At 6 and 9 months postoperatively, comprehensive orthodontic treatment was initiated for the mandible and maxilla, respectively, using orthodontic anchorage devices to achieve acceptable functional occlusion. After orthodontic treatment, staged guided bone regeneration was performed and dental implants were placed in the severely resorbed maxillary anterior ridge. This comprehensive treatment yielded favorable periodontal conditions, stable occlusion, and good esthetic outcomes. CONCLUSIONS AND PRACTICAL IMPLICATIONS: Favorable esthetics, stable occlusion, and highly cleansable periodontal tissues were achieved with well-planned interdisciplinary and comprehensive treatment, although the patient had severe periodontitis and PTM-related bimaxillary protrusion.


Assuntos
Má Oclusão , Periodontite , Migração de Dente , Feminino , Seguimentos , Humanos , Mandíbula , Pessoa de Meia-Idade , Periodontite/complicações , Periodontite/terapia , Migração de Dente/etiologia , Migração de Dente/terapia
9.
Medicine (Baltimore) ; 100(20): e25974, 2021 May 21.
Artigo em Inglês | MEDLINE | ID: mdl-34011085

RESUMO

ABSTRACT: Nerve injury especially inferior alveolar nerve (IAN) is the one of the complications that occur when the mandibular third molar (M3) is extracted and in case of high risk patients, coronectomy might be an alternative to tooth extraction. The purpose of this retrospective study was to analyze root migration and its influencing factors at 6 months after coronectomy in both 2- and 3-dimensions using periapical view and cone-beam computed tomography (CBCT). We analyzed 33 cases of root remnant after coronectomy and measured the amount of migration in CBCT. The following factors that could possibly affect root migration were also analyzed: age, gender, number of M3 roots, shape of M3s, Pell, and Gregory classification, mesiodistal (MD) angulation, buccolingual (BL) angulation, contact point with the second molar, root curvature, and complete removal of the coronal portion. Migration of greater than 2 mm was found in 64% of the roots in the 2-dimensional (2D) analysis, and the average root migration was 4.11 mm in the 3-dimensional (3D) analysis. The factors affecting migration were the root morphology, complete removal of the coronal portion, impaction depth, and MD angulation in the 2D analysis, and MD and BL angulation in the 3D analysis. Ensuring sufficient space for root migration especially considering angulation, depth and complete removal of the coronal portion might be important factors after coronectomy of the M3. Root remnant after coronectomy of M3 may migrate in young patients who has sufficient empty coronal space and this may reduce the nerve damage by the separation of IAN and M3.


Assuntos
Traumatismos do Nervo Mandibular/prevenção & controle , Dente Serotino/cirurgia , Procedimentos Cirúrgicos Bucais/efeitos adversos , Migração de Dente/etiologia , Dente Impactado/cirurgia , Adulto , Tomografia Computadorizada de Feixe Cônico , Feminino , Humanos , Masculino , Mandíbula/diagnóstico por imagem , Mandíbula/inervação , Mandíbula/cirurgia , Nervo Mandibular/diagnóstico por imagem , Traumatismos do Nervo Mandibular/etiologia , Pessoa de Meia-Idade , Dente Serotino/diagnóstico por imagem , Estudos Retrospectivos , Coroa do Dente/cirurgia , Migração de Dente/diagnóstico , Raiz Dentária/diagnóstico por imagem , Adulto Jovem
10.
Clin Oral Investig ; 25(11): 6357-6364, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-33884503

RESUMO

OBJECTIVES: Adult orthodontic treatment, especially in patients over 40 years, is steadily increasing. One causal factor for the treatment need in this age group is periodontal breakdown. The aim of this study was to detect correlations between periodontal problems and orthodontic parameters in interdisciplinary patients. METHODS: This observational, cross-sectional study included 118 patients over 40 years (51 men/67 women; mean age, 58.03 years) classified into three groups according to periodontal breakdown (group I, controls; group II, moderate periodontitis; group III, severe periodontitis). Clinical periodontal and orthodontic parameters as well as the index of orthodontic treatment need (IOTN) were assessed and compared between the groups. RESULTS: A gradual deterioration of all periodontal and orthodontic parameters according to periodontal bone loss (lowest values in group I; highest values in group III) was observed. Especially groups I and III differed significantly regarding the overjet (p < 0.001) and the little indices of the maxilla (p < 0.001) and mandible (p < 0.010). The IOTN was highest in group III: 90% of the patients with severe periodontitis were classified to have moderate to very great treatment need. CONCLUSIONS: The higher the degree of periodontal breakdown was, the more severe were overjet, overbite, irregularity of the anterior teeth, and the orthodontic treatment need. CLINICAL RELEVANCE: Adult patients over 40 years represent a challenge for an orthodontic/periodontal treatment approach with high incidence of pathologic tooth migration, orthodontic treatment need, and periodontal breakdown. Therefore, this special patient collective requires a focus in clinical orthodontics and research.


Assuntos
Perda do Osso Alveolar , Migração de Dente , Adulto , Estudos Transversais , Feminino , Humanos , Incisivo , Masculino , Mandíbula , Pessoa de Meia-Idade
11.
Medicine (Baltimore) ; 100(13): e25181, 2021 Apr 02.
Artigo em Inglês | MEDLINE | ID: mdl-33787598

RESUMO

ABSTRACT: This retrospective study aimed to explore the effect of orthodontic treatment (ODT) on anterior tooth displacement (ATD) caused by periodontal disease (PD).A total of 72 patients were selected and were divided into a control group (n = 36) and an experimental group (n = 36). Patients in both groups received conventional periodontal treatment. In addition, patients in the experimental group also received ODT. Outcomes include probing depth, percentage of bleeding sites, clinical attachment loss, clinical crown length, tooth root length, and periodontal tissue of the affected tooth (alveolar bone height, periodontal pocket depth, bleeding index).After treatment, the patients in the experimental group achieved more improvements in probing depth (P < .01), percentage of bleeding sites (P < .01), clinical attachment loss (P < .01), clinical crown length (P = .04), and periodontal tissue of the affected tooth (periodontal pocket depth (P < .01), and bleeding index (P < .01)), than those of patients in the control group.This study suggests that ODT is beneficial for ATD caused by PD. Future studies are still needed to verify the findings of this study.


Assuntos
Ortodontia Corretiva/métodos , Doenças Periodontais/complicações , Migração de Dente/terapia , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Índice Periodontal , Estudos Retrospectivos , Migração de Dente/etiologia , Resultado do Tratamento
12.
PLoS One ; 16(2): e0247011, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33596270

RESUMO

BACKGROUND: Nicotine exposure has been reported to modify bone cell function and the osseous metabolism with potential effects on the rate of orthodontic tooth movement. OBJECTIVES: To systematically investigate and quantitively synthesize the most recent available evidence from animal studies regarding the effect of nicotine exposure on the rate of orthodontic tooth movement. SEARCH METHODS: Unrestricted searches in 7 databases and hand searching were performed until July 2020 (PubMed, Central, Cochrane Database of Systematic Reviews, SCOPUS, Web of Science, Arab World Research Source, ProQuest Dissertations and Theses Global). SELECTION CRITERIA: We searched for controlled studies on healthy animals investigating the effect of nicotine on the rate of orthodontic tooth movement. DATA COLLECTION AND ANALYSIS: Following study retrieval and selection, relevant data was extracted and the risk of bias was assessed using the SYRCLE's Risk of Bias Tool. Exploratory synthesis and meta-regression were carried out using the random effects model. RESULTS: From the initially identified records, 5 articles meeting the inclusion criteria were selected and no specific concerns regarding bias were identified. Quantitative data synthesis showed that the rate of orthodontic tooth movement in the nicotine exposed rats was higher than in the control group animals (2 weeks of force application; 0.317 mm more movement in nicotine exposed rats; 95% Confidence Interval: 0.179-0.454; p = 0.000). No effect of the concentration or the duration force application was demonstrated following exploratory meta-regression. CONCLUSION: Rats administered with nicotine showed accelerated rates of orthodontic tooth movement. Although, information from animal studies cannot be fully translated to human clinical scenarios, safe practice would suggest that the orthodontist should be able to identify patients exposed to nicotine and consider the possible implications for everyday clinical practice.


Assuntos
Nicotina/farmacologia , Agonistas Nicotínicos/farmacologia , Animais , Reabsorção Óssea/induzido quimicamente , Fumar Cigarros/efeitos adversos , Humanos , Nicotina/administração & dosagem , Nicotina/efeitos adversos , Agonistas Nicotínicos/administração & dosagem , Agonistas Nicotínicos/efeitos adversos , Migração de Dente/induzido quimicamente , Mobilidade Dentária/induzido quimicamente , Técnicas de Movimentação Dentária
13.
Int J Mol Sci ; 22(2)2021 Jan 09.
Artigo em Inglês | MEDLINE | ID: mdl-33435280

RESUMO

Dietary salt uptake and inflammation promote sodium accumulation in tissues, thereby modulating cells like macrophages and fibroblasts. Previous studies showed salt effects on periodontal ligament fibroblasts and on bone metabolism by expression of nuclear factor of activated T-cells-5 (NFAT-5). Here, we investigated the impact of salt and NFAT-5 on osteoclast activity and orthodontic tooth movement (OTM). After treatment of osteoclasts without (NS) or with additional salt (HS), we analyzed gene expression and the release of tartrate-resistant acid phosphatase and calcium phosphate resorption. We kept wild-type mice and mice lacking NFAT-5 in myeloid cells either on a low, normal or high salt diet and inserted an elastic band between the first and second molar to induce OTM. We analyzed the expression of genes involved in bone metabolism, periodontal bone loss, OTM and bone density. Osteoclast activity was increased upon HS treatment. HS promoted periodontal bone loss and OTM and was associated with reduced bone density. Deletion of NFAT-5 led to increased osteoclast activity with NS, whereas we detected impaired OTM in mice. Dietary salt uptake seems to accelerate OTM and induce periodontal bone loss due to reduced bone density, which may be attributed to enhanced osteoclast activity. NFAT-5 influences this reaction to HS, as we detected impaired OTM and osteoclast activity upon deletion.


Assuntos
Perda do Osso Alveolar/metabolismo , Osteoclastos/metabolismo , Osteogênese , Cloreto de Sódio na Dieta/metabolismo , Migração de Dente/metabolismo , Animais , Densidade Óssea , Remodelação Óssea , Masculino , Camundongos , Osteoclastos/citologia , Ligamento Periodontal/metabolismo , Células RAW 264.7 , Fosfatase Ácida Resistente a Tartarato/metabolismo , Fatores de Transcrição/metabolismo
14.
Clin Oral Implants Res ; 32(2): 233-241, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-33258186

RESUMO

OBJECTIVES: To quantify the neighboring and antagonist teeth migration of a single posterior tooth-missing site within 3 months using digital scanning and measuring techniques. MATERIALS AND METHODS: Intraoral scans (IOS) were made in 40 patients presenting a single posterior tooth-missing gap and receiving implant therapy. IOS were obtained at the day of and three months after implant surgery rendering a digital baseline model (BM) and a digital follow-up model (FM). Digital models were superimposed using the implant scan body as reference. Antagonist models were processed by the best fit alignment. Dimensional change between anatomical landmarks on neighboring teeth and that of featuring points on antagonistic teeth were measured using a three-dimensional analysis software. The Mann-Whitney U test was applied to compare the tooth-moving distance between the mesial and distal neighboring teeth. The Kruskal-Wallis one-way ANOVA was used to test the difference in dimensional change in tooth-missing site among age subgroups. RESULTS: The mean dimensional change in the tooth-missing site was -37.62 ± 106.36 µm (median: -28.33 µm, Q25 -72.65/Q75 38.97) mesial-distally and -67.91 ± 42.37 µm (median: -61.50 µm, Q25 -88.25/Q75 -36.75) occlusal-gingivally. Eighteen out of 40 mesial neighboring teeth and 24 out of 40 distal neighboring teeth showed migration towards the implants. When patients were grouped according to age, the mesial-distal reduction in the tooth-missing site was significantly larger in patients younger than 30 years compared with those older than 50 years (p < .05). CONCLUSIONS: The dimensions of posterior tooth-missing sites decreased over an observation period of 3 months.


Assuntos
Implantes Dentários para Um Único Dente , Implantes Dentários , Perda de Dente , Migração de Dente , Dente , Adulto , Implantes Dentários/efeitos adversos , Humanos
15.
Histol Histopathol ; 35(12): 1493-1502, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33179759

RESUMO

Orthodontic tooth movement (OTM) is a specific treatment of malocclusion, whose regulation mechanism is still not clear. This study aimed to reveal the relationship between the sympathetic nervous system (SNS) and OTM through the construction of an OTM rat model through the utilization of orthodontic nickeltitanium coiled springs. The results indicated that the stimulation of SNS by dopamine significantly promote the OTM process represented by the much larger distance between the first and second molar compared with mere exertion of orthodontic force. Superior cervical ganglionectomy (SCGx) can alleviate this promotion effect, further proving the role of SNS in the process of OTM. Subsequently, the ability of orthodontic force to stimulate the center of the SNS was visualized by the tyrosin hydroxylase (TH) staining of neurons in ventromedial hypothalamic nucleus (VMH) and arcuate nucleus (ARC) of the hypothalamus, as well as the up-regulated expression of norepinephrine in local alveolar bone. Moreover, we also elucidated that the stimulation of SNS can promote osteoclast differentiation in periodontal ligament cells (PDLCs) and bone marrow-derived cells (BMCs) through regulation of receptor activator of nuclear factor-κB ligand (RANKL)/osteoprotegerin (OPG) system, thus promoting the OTM process. In conclusion, this study provided the first evidence for the involvement of the hypothalamus in the promotion effect of SNS on OTM. This work could provide a novel theoretical and experimental basis for further understanding of the molecular mechanism of OTM.


Assuntos
Processo Alveolar/fisiologia , Ligamento Periodontal/fisiologia , Gânglio Cervical Superior/fisiologia , Migração de Dente , Mobilidade Dentária , Técnicas de Movimentação Dentária , Núcleo Hipotalâmico Ventromedial/fisiologia , Processo Alveolar/inervação , Processo Alveolar/metabolismo , Animais , Células Cultivadas , Dopamina/farmacologia , Ganglionectomia , Masculino , Mecanotransdução Celular , Norepinefrina/metabolismo , Osteoclastos/fisiologia , Osteogênese , Osteoprotegerina/metabolismo , Ligamento Periodontal/inervação , Ligamento Periodontal/metabolismo , Ligante RANK/metabolismo , Ratos Sprague-Dawley , Gânglio Cervical Superior/cirurgia , Núcleo Hipotalâmico Ventromedial/efeitos dos fármacos
16.
Am J Orthod Dentofacial Orthop ; 158(1): 16-27, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32381434

RESUMO

INTRODUCTION: Physiological root resorption is a common occurrence in mammalian teeth, which suggests that there must be a corollary consisting of physiological cementum repair. The mechanism(s) responsible for this physiological repair process is unknown and was the focus of this study. METHODS: Using a rat model, we explored first the prevalence of physiological root resorption and then asked whether this prevalence changed as a result of an osteoporotic phenotype. The cellular mechanisms of resorption were characterized using a combination of finite element modeling coupled with in-vivo histologic, molecular, and cellular analyses in rats. A potential molecular mechanism for cementum repair was uncovered using a strain of transgenic mice in which Wnt-responsive cells could be labeled and followed over time. RESULTS: In rats, most resorption lacunae were concentrated on the distal surfaces of the roots. Rat molars undergo a physiological tooth drift distally, and using finite element modeling, we calculated the magnitude of the compressive strains that accumulated on these surfaces in response to mastication. Although the overall strain magnitudes were low, they were constant and coincided with the presence of resorption lacunae. Where resorption lacunae were present, progeny from a Wnt-responsive population of stem cells, embedded in the periodontal ligament, directly contributed to the repair of the lacunae. CONCLUSIONS: Despite the fact that both are clastic conditions, an osteoporotic phenotype in rats was not associated with an increase in the prevalence of physiological root resorption. The location of the resorption lacunae corresponded to sites of low but constant compressive strains produced by physiological distal drift. At least 1 mechanism responsible for physiological cementum repair involved the contribution of Wnt-responsive stem or progenitor cells originating in the periodontal ligament. These data point toward a potential Wnt-based strategy to regenerate cementum in subjects with disease or damage.


Assuntos
Reabsorção da Raiz , Migração de Dente , Animais , Cemento Dentário , Camundongos , Ligamento Periodontal , Ratos , Raiz Dentária , beta Catenina
17.
PLoS One ; 14(10): e0223989, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31618254

RESUMO

Compressive force during orthodontic tooth movement induces osteoclast formation in vivo. TNF-α plays an important role in mouse osteoclast formation and bone resorption induced by compressive force during orthodontic tooth movement. Stromal cells, macrophages and T cells take part in TNF-α-induced osteoclast formation in vitro. Root resorption caused by odontoclasts is a major clinical problem during orthodontic tooth movement. In this study, we determined the cell type targeted by TNF-α during compressive-force-induced osteoclast and odontoclast formation to elucidate the mechanism of bone and root resorption in vivo. An orthodontic tooth movement mouse model was prepared with a nickel-titanium closed coil spring inserted between the maxillary incisors and the first molar. Using TNF receptor 1- and 2-deficient (KO) mice, we found that osteoclast and odontoclast formation was mediated by TNF-α in orthodontic tooth movement. We generated four types of chimeric mice: wild-type (WT) bone marrow cells transplanted into lethally irradiated WT mice (WT>WT), KO bone marrow cells transplanted into lethally irradiated WT mice (KO>WT), WT bone marrow cells transplanted into lethally irradiated KO mice (WT>KO), and KO marrow cells transplanted into lethally irradiated KO mice (KO>KO). Using anti-CD4 and anti-CD8 antibodies, T cells were eliminated from these mice. We subjected these chimeric mice to orthodontic tooth movement. Orthodontic tooth movement was evaluated and tartrate-resistant acid phosphatase-positive cells along the alveolar bone (osteoclasts) and along the tooth root (odontoclasts) were counted after 12 days of tooth movement. The amount of orthodontic tooth movement, and the number of osteoclasts and odontoclasts on the compression side were significantly lower in WT>KO and KO>KO mice than in WT>WT and KO>WT mice. According to these results, we concluded that TNF-α-responsive stromal cells are important for osteoclast and odontoclast formation during orthodontic tooth movement.


Assuntos
Osteoclastos/citologia , Células Estromais/citologia , Migração de Dente/metabolismo , Fator de Necrose Tumoral alfa/metabolismo , Animais , Modelos Animais de Doenças , Masculino , Camundongos , Osteoclastos/metabolismo , Receptores Tipo I de Fatores de Necrose Tumoral/deficiência , Receptores Tipo II do Fator de Necrose Tumoral/deficiência , Células Estromais/metabolismo
18.
Sci Rep ; 9(1): 14549, 2019 10 10.
Artigo em Inglês | MEDLINE | ID: mdl-31601925

RESUMO

We assessed the three-dimensional (3D) pattern of the physiologic drift of the remaining adjacent teeth after premolar extraction due to orthodontic reasons and the associated factors. Data were collected from 45 patients aged 17.04 ± 5.14 years who were scheduled to receive a fixed appliance after maxillary premolar extraction. Seventy-five drift models were obtained and digitalized via 3D scanning. The average physiologic drift duration was 81.66 ± 70.03 days. Angular and linear changes in the first molars, second premolars, and canines were measured using the 3D method. All the examined teeth had tipped and moved towards the extraction space, leading to space decreases. Posterior teeth primarily exhibited significant mesial tipping and displacement, without rotation or vertical changes. All canine variables changed, including distal inward rotation and extrusion. The physiologic drift tended to slow over time. Age had a limited negative effect on the mesial drift of posterior teeth, whereas crowding had a limited positive effect on canine drift. Thus, the mesial drift of molars after premolar extraction may lead to molar anchorage loss, particularly among younger patients. The pattern of the physiologic drift of maxillary canines can help relieve crowding and facilitate labially ectopic canine alignment, whereas canine drift is accelerated by more severe crowding.


Assuntos
Dente Pré-Molar/cirurgia , Imageamento Tridimensional , Extração Dentária , Migração de Dente , Adolescente , Adulto , Cefalometria , Criança , Feminino , Humanos , Masculino , Ortodontia , Análise de Regressão , Adulto Jovem
19.
J Pak Med Assoc ; 69(9): 1385-1389, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31511732

RESUMO

Poor aesthetics due to gingival recession can be a common concern among patients, specifically in individuals with gummy or high smile line. Various factors including patient related, site specific and technical factors need to be considered while treating gingival recession, as they all have a significant bearing on treatment success. Patients having aesthetic problems due to exposed root surfaces should have surgical root coverage procedures. Pathologic migration of anterior teeth is another aesthetic and functional problem that may be associated with advanced or chronic periodontal disease. Literature suggests the destruction of periodontal supporting structures to be the most commonly associated factor responsible for pathologic tooth migration. This case report is about the management of dental aesthetics of a middle-aged lady who was concerned about recession and pathologic tooth migration secondary to chronic periodontal disease. Employing multidisciplinary approach that included surgery, periodontics, endodontic and prosthodontics, the lady was provided with an aesthetically pleasing dentition.


Assuntos
Cárie Dentária/terapia , Estética Dentária , Retração Gengival/terapia , Satisfação do Paciente , Doenças Periodontais/terapia , Migração de Dente/terapia , Adulto , Coroas , Prótese Parcial Fixa , Feminino , Humanos , Equipe de Assistência ao Paciente , Tratamento do Canal Radicular , Extração Dentária
20.
J Biol Regul Homeost Agents ; 33(3 Suppl. 1): 121-127. DENTAL SUPPLEMENT, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31538458

RESUMO

Only in recent times has been enhanced the importance of gingival crevicular fluid in periodontal health and in particular in maintaining the integrity of periodontium during application of orthodontic forces. The aim of this short review is to evaluate the importance of substances as valid biomarkers of periodontal health during orthodontic movements. A search on PubMed and Cochrane database was performed considering the literature from 2003 to 2014, using the following key words: gingival crevicular fluid, biomarkers of periodontal tissue, orthodontic movements. After abstracts screening, the full-texts of selected papers were analyzed and the papers found from the reference lists were also considered. The search focused on clinical applications documented in studies in the English language: levels of evidence included in the literature analysis were I, II and III. Literature analysis showed 28 papers that fulfilled the inclusion criteria. The conclusion is that GCF is a powerful vehicle for clinical diagnostics, since it contains different biochemical and cellular arrays in relation to different clinical situations indicative of the state of periodontal health during orthodontic treatment.


Assuntos
Líquido do Sulco Gengival/química , Periodonto/patologia , Migração de Dente , Biomarcadores/química , Humanos
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